Beyond PCOS: How PMOS Better Explains Hormonal Imbalance and Progesterone Deficiency

For years this condition has been called PCOS, yet the name never truly reflected what was happening in the body. The ovaries are only one part of the picture. Many women with so-called “cysts” have none at all, while others suffer from profound hormonal and metabolic disturbances that affect the entire endocrine system. The newer term PMOS, Polyendocrine Metabolic Ovarian Syndrome, is more accurate and long overdue.

PMOS is driven by a complex interaction between insulin, excess androgens, inflammation, stress hormones and disrupted ovulation. Symptoms can include irregular cycles, weight gain, acne, hair growth, infertility, anxiety and fatigue. It is not simply an ovarian disorder, but a whole-body condition affecting metabolism, hormones and reproductive health together.

We have always maintained that progesterone deficiency lies at the heart of many of these symptoms. When ovulation is disrupted, progesterone drops, oestrogen dominance rises, and the cascade of symptoms begins. Restoring balance naturally remains one of the most important steps in supporting women with PMOS.

Read more on our dedicated pages: PCOS and PMOS.